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Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination.
Davis, Carl W; Jackson, Katherine J L; McCausland, Megan M; Darce, Jaime; Chang, Cathy; Linderman, Susanne L; Chennareddy, Chakravarthy; Gerkin, Rebecca; Brown, Shantoria J; Wrammert, Jens; Mehta, Aneesh K; Cheung, Wan Cheung; Boyd, Scott D; Waller, Edmund K; Ahmed, Rafi.
Afiliación
  • Davis CW; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
  • Jackson KJL; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • McCausland MM; Department of Pathology, Stanford University, Stanford, CA, USA.
  • Darce J; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
  • Chang C; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • Linderman SL; Cell Signaling Technology, Inc., Danvers, MA, USA.
  • Chennareddy C; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
  • Gerkin R; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • Brown SJ; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
  • Wrammert J; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • Mehta AK; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
  • Cheung WC; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • Boyd SD; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
  • Waller EK; Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
  • Ahmed R; Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta GA, USA.
Science ; 370(6513): 237-241, 2020 10 09.
Article en En | MEDLINE | ID: mdl-32792465
A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPCs), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPCs 4 weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their prevaccination levels after 1 year. This decline was driven by the loss of BMPCs induced by the vaccine, whereas preexisting BMPCs were maintained. Our results suggest that most BMPCs generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Células de la Médula Ósea / Vacunas contra la Influenza / Gripe Humana Límite: Animals / Humans Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Células de la Médula Ósea / Vacunas contra la Influenza / Gripe Humana Límite: Animals / Humans Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos