Deletion of the Histone Deacetylase HdaA in Endophytic Fungus <i>Penicillium chrysogenum</i> Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression.

Ding, Zhuang; Zhou, Haibo; Wang, Xiao; Huang, Huiming; Wang, Haotian; Zhang, Ruiyan; Wang, Zhengping; Han, Jun

Deletion of the Histone Deacetylase HdaA in Endophytic Fungus Penicillium chrysogenum Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression.

Ding, Zhuang; Zhou, Haibo; Wang, Xiao; Huang, Huiming; Wang, Haotian; Zhang, Ruiyan; Wang, Zhengping; Han, Jun.

Afiliación

Ding Z; Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Zhou H; Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Wang X; Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Huang H; School of Life Science, Liaocheng University, Liaocheng 252059, China.
Wang H; Faculty of Pharmacy, Bengbu Medical College, Bengbu 233000, China.
Zhang R; Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Wang Z; Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.
Han J; Institute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, China.

Molecules ; 25(16)2020 Aug 11.

Article en En | MEDLINE | ID: mdl-32796640

Asunto(s)

Ficus/microbiología; Eliminación de Gen; Histona Desacetilasas/genética; Alcaloides Indólicos/metabolismo; Familia de Multigenes; Penicillium chrysogenum/metabolismo; Metabolismo Secundario; Productos Biológicos/metabolismo; Células HL-60; Histona Desacetilasas/química; Histona Desacetilasas/metabolismo; Humanos; Células K562; Penicillium chrysogenum/genética; Penicillium chrysogenum/crecimiento & desarrollo

Palabras clave

Penicillium chrysogenum; endophytic fungi; meleagrin; metabolic regulation; roquefortine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicillium chrysogenum / Familia de Multigenes / Eliminación de Gen / Ficus / Alcaloides Indólicos / Metabolismo Secundario / Histona Desacetilasas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China

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