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Strepyrazinone, a tricyclic diketopiperazine derivative with cytotoxicity from a marine-derived actinobacterium.
Zhang, Lu; Feng, Ling-Ling; Wang, Guang-Fei; Yang, Qiao-Li; Fu, Xin-Zhen; Li, Zhi; Liu, Ming; Kou, Li-Juan; Xu, Bo; Xie, Ze-Ping; Zhang, Shu-Min; Guo, Lin.
Afiliación
  • Zhang L; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Feng LL; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Wang GF; College of Life Sciences, Yantai University, Yantai 264005, China.
  • Yang QL; College of Life Sciences, Yantai University, Yantai 264005, China.
  • Fu XZ; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Li Z; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Liu M; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Kou LJ; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Xu B; College of Life Sciences, Yantai University, Yantai 264005, China.
  • Xie ZP; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
  • Zhang SM; Shandong International Biotechnology Park, Yantai 264670, China.
  • Guo L; School of Pharmacy, Binzhou Medical University, Yantai 264003, China.
J Asian Nat Prod Res ; 23(10): 968-974, 2021 Oct.
Article en En | MEDLINE | ID: mdl-32819169
ABSTRACT
Strepyrazinone (1), a tricyclic diketopiperazine derivative with a carbon skeleton unprecedented in natural products, was isolated from the marine-derived Streptomyces sp. B223. Its structure was elucidated by spectroscopic analyses and electronic circular dichroism calculation. Compound 1 showed cytotoxic activity against HCT-116 cancer cell lines with an IC50 value of 0.34 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Antineoplásicos Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Antineoplásicos Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China