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Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study.
Young, Barnaby E; Fong, Siew-Wai; Chan, Yi-Hao; Mak, Tze-Minn; Ang, Li Wei; Anderson, Danielle E; Lee, Cheryl Yi-Pin; Amrun, Siti Naqiah; Lee, Bernett; Goh, Yun Shan; Su, Yvonne C F; Wei, Wycliffe E; Kalimuddin, Shirin; Chai, Louis Yi Ann; Pada, Surinder; Tan, Seow Yen; Sun, Louisa; Parthasarathy, Purnima; Chen, Yuan Yi Constance; Barkham, Timothy; Lin, Raymond Tzer Pin; Maurer-Stroh, Sebastian; Leo, Yee-Sin; Wang, Lin-Fa; Renia, Laurent; Lee, Vernon J; Smith, Gavin J D; Lye, David Chien; Ng, Lisa F P.
Afiliación
  • Young BE; National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Fong SW; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
  • Chan YH; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Mak TM; National Public Health Laboratory, Singapore.
  • Ang LW; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore.
  • Anderson DE; Duke-NUS Medical School, National University of Singapore, Singapore.
  • Lee CY; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Amrun SN; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Lee B; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Goh YS; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Su YCF; Duke-NUS Medical School, National University of Singapore, Singapore.
  • Wei WE; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore.
  • Kalimuddin S; Duke-NUS Medical School, National University of Singapore, Singapore; Department of Infectious Diseases, Singapore General Hospital, Singapore.
  • Chai LYA; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Medicine, National University Health System, Singapore.
  • Pada S; Department of Medicine, Infectious Diseases Service, Ng Teng Fong General Hospital, Singapore.
  • Tan SY; Department of Infectious Diseases, Changi General Hospital, Singapore.
  • Sun L; Alexandra Hospital, Singapore.
  • Parthasarathy P; Department of General Medicine, Khoo Teck Puat Hospital, Singapore.
  • Chen YYC; Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore.
  • Barkham T; Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Lin RTP; National Public Health Laboratory, Singapore.
  • Maurer-Stroh S; National Centre for Infectious Diseases, Singapore; Bioinformatics Institute, Agency for Science, Technology, and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore; Global Initiative on Sharing All Influenza Data, Munich, Germany.
  • Leo YS; National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School
  • Wang LF; Duke-NUS Medical School, National University of Singapore, Singapore.
  • Renia L; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore.
  • Lee VJ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Ministry of Health, Singapore.
  • Smith GJD; Duke-NUS Medical School, National University of Singapore, Singapore. Electronic address: gavin.smith@duke-nus.edu.sg.
  • Lye DC; National Centre for Infectious Diseases, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • Ng LFP; Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology, and Research, Singapore; Singapore Immunology Network, Agency for Science, Technology, and Research, Singapore. Electronic address: lisa_ng@immunol.a-star.edu.sg.
Lancet ; 396(10251): 603-611, 2020 08 29.
Article en En | MEDLINE | ID: mdl-32822564

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Genoma Viral / Eliminación de Gen / Infecciones por Coronavirus Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Genoma Viral / Eliminación de Gen / Infecciones por Coronavirus Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Lancet Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido