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Long-Term Effect of Environmental Enrichment on Reproductive Performance of Swiss Webster Mice and Their Female Offspring.
Meikle, María Noel; Arévalo, Ana Paula; Schlapp, Geraldine; Fernández-Graña, Gabriel; Menchaca, Alejo; Crispo, Martina.
Afiliación
  • Meikle MN; Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, CP 11400, Uruguay.
  • Arévalo AP; Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, CP 11400, Uruguay.
  • Schlapp G; Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, CP 11400, Uruguay.
  • Fernández-Graña G; Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, CP 11400, Uruguay.
  • Menchaca A; Instituto de Reproducción Animal Uruguay, Cno Cruz del Sur 2250 Montevideo 12200, Uruguay.
  • Crispo M; Unidad de Animales Transgénicos y de Experimentación (UATE), Institut Pasteur de Montevideo, Mataojo 2020, Montevideo, CP 11400, Uruguay.
Animals (Basel) ; 10(8)2020 Aug 18.
Article en En | MEDLINE | ID: mdl-32824668
ABSTRACT
The aim of this study was to evaluate the effect of an environmental enrichment (EE) plan on the reproductive performance of Swiss Webster mice and their female offspring used as recipients for embryo transfer. A total of 54 breeder mice and 60 F1 females, used as foster mothers, were allocated in two experimental groups to receive or not receive EE for physical well-being. Reproductive outcomes of the Swiss trios such as birth rate and pup number, litter size, pups' weight at weaning, interlitter interval and time to first litter were analyzed. Environmental enrichment significantly increased pups weight from breeding trios compared to the control group (14.4 ± 0.1 vs. 13.8g ± 0.1, EE vs. control, respectively; p < 0.01). Other parameters did not differ between both groups. Reproductive parameters of female offspring used as recipients for embryo transfer did not differ among groups subjected or not to EE. These data demonstrate that the EE protocol applied in Swiss Webster breeder mice positively enhanced pups weight, and did not interfere with other reproductive outcomes. In conclusion, this study supports the implementation of EE plans usually applied for animal welfare in mouse facilities with slight improvement in reproductive performance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animals (Basel) Año: 2020 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animals (Basel) Año: 2020 Tipo del documento: Article