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The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries).
Sakthivel, Dhanasekaran; Preston, Sarah; Gasser, Robin B; Costa, Tatiana P Soares da; Hernandez, Julia N; Shahine, Adam; Shakif-Azam, M D; Lock, Peter; Rossjohn, Jamie; Perugini, Matthew A; González, Jorge Francisco; Meeusen, Els; Piedrafita, David; Beddoe, Travis.
Afiliación
  • Sakthivel D; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • Preston S; School of Science, Psychology and, Sport, Federation University, Churchill, VIC, 3842, Australia.
  • Gasser RB; Department of Animal, Plant and Soil Science and Centre for Agri Bioscience (Agri Bio), La Trobe University, Bundoora, VIC, 3086, Australia.
  • Costa TPSD; School of Science, Psychology and, Sport, Federation University, Churchill, VIC, 3842, Australia.
  • Hernandez JN; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Bundoora, VIC, 3010, Australia.
  • Shahine A; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
  • Shakif-Azam MD; Instituto Universitario de Sanidad Animal, Faculty of Veterinary Medicine, Universidad de Las Palmas de Gran Canaria, Arucas, Spain.
  • Lock P; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • Rossjohn J; School of Science, Psychology and, Sport, Federation University, Churchill, VIC, 3842, Australia.
  • Perugini MA; Bioimaging Platform, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
  • González JF; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • Meeusen E; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, 3800, Australia.
  • Piedrafita D; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
  • Beddoe T; Instituto Universitario de Sanidad Animal, Faculty of Veterinary Medicine, Universidad de Las Palmas de Gran Canaria, Arucas, Spain.
Commun Biol ; 3(1): 464, 2020 08 21.
Article en En | MEDLINE | ID: mdl-32826940
ABSTRACT
Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Galectinas / Multimerización de Proteína / Antiparasitarios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Galectinas / Multimerización de Proteína / Antiparasitarios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Commun Biol Año: 2020 Tipo del documento: Article País de afiliación: Australia