Chiral Bicyclo[2.2.2]octane-Fused CpRh Complexes: Synthesis and Potential Use in Asymmetric C-H Activation.
Angew Chem Int Ed Engl
; 59(50): 22436-22440, 2020 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-32840946
ABSTRACT
A new class of chiral cyclopentadienyl rhodium(I) complexes (CpRhI ) bearing C2 -symmetric chiral bridged-ring-fused Cp ligands was prepared. The complexes were successfully applied to the asymmetric C-H activation reaction of N-methoxybenzamides with quinones, affording a series of chiral hydrophenanthridinones in up to 82 % yield with up to 99 % ee. Interestingly, structure analysis reveals that the side wall of the optimal chiral CpRhI catalyst is vertically more extended, horizontally less extended, and closer to the metal center in comparison with the classic binaphthyl and spirobiindanyl CpRhI complexes, and may thus account for its superior catalytic performance.
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01-internacional
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MEDLINE
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En
Revista:
Angew Chem Int Ed Engl
Año:
2020
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Article