CD38 as an immunomodulator in cancer.
Future Oncol
; 16(34): 2853-2861, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-32857612
ABSTRACT
CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 protein was previously considered as a cell activation marker, and today monoclonal antibodies targeting CD38 have witnessed great achievements in multiple myeloma and promoted researchers to conduct research on other tumors. In this review, we provide a wide-ranging review of the biology and function of the human molecule outside the field of myeloma. We focus mainly on current research findings to summarize and update the findings gathered from diverse areas of study. Based on these findings, we attempt to extend the role of CD38 in the context of therapy of solid tumors and expand the role of the molecule from a simple marker to an immunomodulator.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADP-Ribosil Ciclasa 1
/
Factores Inmunológicos
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Future Oncol
Año:
2020
Tipo del documento:
Article