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Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits.
Lopes, André T; Hausrat, Torben J; Heisler, Frank F; Gromova, Kira V; Lombino, Franco L; Fischer, Timo; Ruschkies, Laura; Breiden, Petra; Thies, Edda; Hermans-Borgmeyer, Irm; Schweizer, Michaela; Schwarz, Jürgen R; Lohr, Christian; Kneussel, Matthias.
Afiliación
  • Lopes AT; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hausrat TJ; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heisler FF; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Gromova KV; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lombino FL; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fischer T; Division of Neurophysiology, University of Hamburg, Hamburg, Germany.
  • Ruschkies L; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Breiden P; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Thies E; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Hermans-Borgmeyer I; Transgenic Animal Unit, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schweizer M; Morphology Unit, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schwarz JR; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lohr C; Division of Neurophysiology, University of Hamburg, Hamburg, Germany.
  • Kneussel M; Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
PLoS Biol ; 18(8): e3000820, 2020 08.
Article en En | MEDLINE | ID: mdl-32866173
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Cinesinas / Ácido Glutámico / Espastina / Trastornos de la Memoria / Memoria a Corto Plazo / Neuronas Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Cinesinas / Ácido Glutámico / Espastina / Trastornos de la Memoria / Memoria a Corto Plazo / Neuronas Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos