HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer.

Zhao, Jing; Krishnamurti, Uma; Zhang, Chao; Meisel, Jane; Wei, Zhimin; Suo, Aili; Aneja, Ritu; Li, Zaibo; Li, Xiaoxian

Zhao, Jing; Krishnamurti, Uma; Zhang, Chao; Meisel, Jane; Wei, Zhimin; Suo, Aili; Aneja, Ritu; Li, Zaibo; Li, Xiaoxian.

Afiliación

Zhao J; Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Krishnamurti U; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States.
Zhang C; Biostatistics and Bioinformatics Shared Resource, Emory University, Atlanta, GA, United States.
Meisel J; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, United States.
Wei Z; Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Suo A; Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Aneja R; Department of Biology, Georgia State University, Atlanta, GA, United States.
Li Z; Department of Pathology, Ohio State University, Columbus, OH, United States.
Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States. Electronic address: xli40@emory.edu.

Pathol Res Pract ; 216(11): 153155, 2020 Nov.

Article en En | MEDLINE | ID: mdl-32871536

Asunto(s)

Antineoplásicos/uso terapéutico; Biomarcadores de Tumor/análisis; Neoplasias de la Mama/tratamiento farmacológico; Receptor ErbB-2/análisis; Adulto; Anciano; Anticuerpos Monoclonales Humanizados/uso terapéutico; Neoplasias de la Mama/metabolismo; Quimioterapia Adyuvante/métodos; Femenino; Humanos; Inmunohistoquímica; Hibridación Fluorescente in Situ; Persona de Mediana Edad; Terapia Molecular Dirigida/métodos; Terapia Neoadyuvante/métodos; Trastuzumab/uso terapéutico; Resultado del Tratamiento

Palabras clave

HER2 heterogeneity; HER2 targeted therapy; HER2+ breast cancer; Immunohistochemistry staining pattern; Neoadjuvant therapy; Predictive; Response

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Receptor ErbB-2 / Antineoplásicos Tipo de estudio: Guideline / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Pathol Res Pract Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania

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