Maturity-Onset diabetes of the young type 5 treated with the glucagon-like peptide-1 receptor agonist: A case report.
Medicine (Baltimore)
; 99(35): e21939, 2020 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-32871938
ABSTRACT
RATIONALE Maturity-onset diabetes of the young type 5 (MODY 5) is a form of monogenic diabetes that is often accompanied by pancreatic dysfunction. To date, no cases of MODY 5 treated with glucagon-like peptide-1 receptor agonist (GLP-1RA) have been reported. We present the first case of MODY 5 treated with GLP-1RA. PATIENT CONCERNS A 17-year-old woman, with a history of being operated for congenital ileal atresia at birth, was admitted to our hospital due to hyperglycemia. She had been clinically diagnosed with type 1 diabetes 1 month prior, and administered 14 units of insulin glargine 300âU/mL per day. DIAGNOSIS She had hypopotassemia, hypomagnesaemia, pancreatic body, and tail defects, multiple renal cysts, and a family history of diabetes, and urogenital anomaly. Genetic testing revealed heterozygous deletion of hepatocyte nuclear transcription factor-1 beta, leading to the diagnosis of MODY 5. INTERVENTIONS:
The patient was treated with multiple daily insulin injections for 9 days (22âunits/d) before administration of GLP-1RA, and then liraglutide was initiated.OUTCOMES:
Liraglutide treatment (0.6âmg/d) alone maintained the patient's glycated hemoglobin level below 7.0% for at least 12 months after discharge. A higher dose, 0.9âmg/d, of liraglutide was not tolerated by the patient due to nausea. Serum levels of C-peptide immunoreactivity were 1.15âng/mL and 1.91âng/mL, respectively, after 6 and 12 months of liraglutide therapy. LESSONS GLP-1RA might be effective at regulating glucose metabolism by utilizing residual pancreatic endocrine function in patients with MODY 5. Imaging and genetic screening were helpful in the diagnosis of MODY 5.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Sistema Nervioso Central
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Esmalte Dental
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Diabetes Mellitus Tipo 2
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Enfermedades Renales Quísticas
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Liraglutida
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Receptor del Péptido 1 Similar al Glucagón
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Hipoglucemiantes
Límite:
Adolescent
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Female
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Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2020
Tipo del documento:
Article