The genotoxicological assessment of a tobacco heating product relative to cigarette smoke using the <i>in vitro</i> micronucleus assay.

Thorne, David; Whitwell, James; Clements, Julie; Walker, Paul; Breheny, Damien; Gaca, Marianna

The genotoxicological assessment of a tobacco heating product relative to cigarette smoke using the in vitro micronucleus assay.

Thorne, David; Whitwell, James; Clements, Julie; Walker, Paul; Breheny, Damien; Gaca, Marianna.

Afiliación

Thorne D; British American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
Whitwell J; Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK.
Clements J; Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire HG3 1PY, UK.
Walker P; Cyprotex Discovery, Alderley Park, Alderley, Cheshire, SK10 4TG, UK.
Breheny D; British American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.
Gaca M; British American Tobacco, R&D, Southampton, Hampshire, SO15 8TL, UK.

Toxicol Rep ; 7: 1010-1019, 2020.

Article en En | MEDLINE | ID: mdl-32874925

Palabras clave

3R4F, Research reference cigarette; CHO; CRM, 81 CORESTA recommended method 81; DMSO, dimethyl sulphoxide; E-cigarette, electronic cigarette; HCI, Health Canada Intense smoking regimen; HCIm, Health Canada Intense modified smoking regimen; High content screening; ISO, International Standards Organisation; IVMN; IVMN, in vitro micronucleus assay; In vitro; NGP, Next generation products; S9, mammalian liver post-mitochondrial fraction; THP, tobacco heating product; TK6; TPM, total particulate matter; Tobacco heating product; V79

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Toxicol Rep Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Irlanda

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