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Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk.
Fedeli, Ugo; Porreca, Angelo; Colicchia, Michele; Schievano, Elena; Artibani, Walter; Biasio, Luigi Roberto; Palù, Giorgio.
Afiliación
  • Fedeli U; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
  • Porreca A; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Colicchia M; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Schievano E; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
  • Artibani W; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Biasio LR; University Contract Lecturer inVaccinology , Rome, Italy.
  • Palù G; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
Hum Vaccin Immunother ; 17(2): 416-417, 2021 Feb 01.
Article en En | MEDLINE | ID: mdl-32880510
It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of BCG, in particular in patients partially immunocompromised. Confirmation by larger prospective studies is required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacuna BCG / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Hum Vaccin Immunother Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacuna BCG / COVID-19 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Hum Vaccin Immunother Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos