The transcriptional factors CDX2 and FOXA1 in chordomas.
Pathol Res Pract
; 216(11): 153160, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32911347
ABSTRACT
Chordomas are rare osseous tumors believed to originate from notochordal remnants through brachyury activation. CDX2 and FOXA1 are both induced by brachyury, but their expression has not been studied in chordomas. We retrospectively studied the immunohistochemical expression of these two factors in 57 chordomas, finding that CDX2 is not expressed in these tumors. FOXA1 expression was found in 7 (12.3%) tumors. No association of FOXA1 expression with clinical factors was found. Thus, CDX2 expression is not a feature of chordomas, while a limited expression of FOXA1 is seen.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Óseas
/
Cordoma
/
Biomarcadores de Tumor
/
Factor Nuclear 3-alfa del Hepatocito
/
Factor de Transcripción CDX2
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Pathol Res Pract
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia