Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells.
Biomed Pharmacother
; 131: 110724, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32920518
ABSTRACT
Stachydrine is a main active component of Leonurus japonicus (Chinese motherwort), which has traditionally been used to promote postpartum recovery and alleviate myocardial and cerebral ischemic injuries due to its pro-angiogenic effect. Our prior study demonstrated that stachydrine increased angiogenesis in zebrafish embryos, but its pro-angiogenic effect and underlying mechanisms on human umbilical vein endothelial cells (HUVECs) remain largely unknown. In the present study, we further investigated the role of stachydrine in sunitinib-injured HUVECs and its potential molecular mechanisms. The results showed that stachydrine exhibited a protective effect on sunitinib-injured HUVECs and significantly promoted their proliferation, migration, and tube formation, all central events of angiogenesis. In addition, stachydrine inhibited apoptosis and ROS production in sunitinib-injured HUVECs. Furthermore, our findings illustrated for the first time that stachydrine's molecular mechanisms for promoting angiogenesis might correlate with activation of the VEGFR2/MEK/ERK and inhibition of the mitochondrial-mediated apoptosis signaling pathway.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prolina
/
Apoptosis
/
Neovascularización Fisiológica
/
Quinasas de Proteína Quinasa Activadas por Mitógenos
/
Receptor 2 de Factores de Crecimiento Endotelial Vascular
/
Quinasas MAP Reguladas por Señal Extracelular
/
Células Endoteliales de la Vena Umbilical Humana
/
Mitocondrias
Límite:
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Año:
2020
Tipo del documento:
Article
País de afiliación:
China