BK polyomavirus infection promotes growth and aggressiveness in bladder cancer.
Virol J
; 17(1): 139, 2020 09 14.
Article
en En
| MEDLINE
| ID: mdl-32928222
ABSTRACT
BACKGROUND:
Recent studies have confirmed the integration of the BK polyomavirus (BKPyV) gene into the cellular genome of urothelial carcinomas in transplant recipients, further confirming the correlation between BKPyV and urothelial carcinomas after transplantation. However, the role BKPyV infections play in the biological function of bladder cancer remains unclear.METHODS:
We developed a BKPyV-infected bladder cancer cell model and a mice tumor model to discuss the role of BKPyV infections.RESULTS:
Our research proves that BKPyV infections promote the proliferation, invasion and migration of bladder cancer cells, while the activation of ß-catenin signaling pathway is one of its mediation mechanisms.CONCLUSIONS:
We first described BKPyV infection promotes the proliferation, invasion and migration of bladder cancer. We verified the role of ß-catenin signaling pathway and Epithelial-Mesenchymal Transition effect in BKPyV-infected bladder cancer. These results provide meaningful information towards the diagnosis and treatment of clinical bladder cancer.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Tumorales por Virus
/
Neoplasias de la Vejiga Urinaria
/
Virus BK
/
Infecciones por Polyomavirus
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Virol J
Asunto de la revista:
VIROLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China