Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector.
Chem Commun (Camb)
; 56(82): 12371-12374, 2020 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-32930253
ABSTRACT
The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole-imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón