Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector.

Hidaka, Takuya; Tsubono, Yutaro; Hashiya, Kaori; Bando, Toshikazu; Pandian, Ganesh N; Sugiyama, Hiroshi

Hidaka, Takuya; Tsubono, Yutaro; Hashiya, Kaori; Bando, Toshikazu; Pandian, Ganesh N; Sugiyama, Hiroshi.

Afiliación

Hidaka T; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

Chem Commun (Camb) ; 56(82): 12371-12374, 2020 Oct 21.

Article en En | MEDLINE | ID: mdl-32930253

ABSTRACT

ABSTRACT

The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole-imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Japón

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