Latamoxef induced a severe coagulation disorder in older patients in China: Two case reports.
J Clin Pharm Ther
; 46(1): 227-229, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-32949406
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
We present two cases of severe coagulation disorders induced by latamoxef, thereby revealing risk factors of coagulation disorder in latamoxef-treated patients. CASESUMMARY:
Two very elderly patients developed haemorrhage, and coagulation tests showed a longer prothrombin time (PT), activated partial thromboplastin time (APTT) and a high international normalized ratio (INR). Latamoxef was thought to be responsible for the coagulopathy in these patients, and coagulation disorder was relieved after vitamin-K intake. WHAT IS NEW ANDCONCLUSION:
We report on two cases of coagulopathy in patients given latamoxef. Advanced age, deficiency in vitamin-K intake, poor nutritional status, abnormal coagulation history, ongoing anti-coagulation/anti-aggregation therapy, renal dysfunction and polypharmacy are possible contributory factors, and should be looked out for when prescribing latamoxef.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Coagulación Sanguínea
/
Neumonía Bacteriana
/
Antibacterianos
/
Moxalactam
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China