When Therapeutic IgA Antibodies Might Come of Age.
Pharmacology
; 106(1-2): 9-19, 2021.
Article
en En
| MEDLINE
| ID: mdl-32950975
ABSTRACT
BACKGROUND:
Extensive efforts have been made in optimizing monoclonal immunoglobulin (Ig)G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti-FcαRI could also represent an exciting avenue toward novel therapeutic strategies.SUMMARY:
Here, we underline that IgA is more effective in recruiting neutrophils for tumor cell killing and is potently active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. IgA could also be used to modulate excessive immune responses in inflammatory diseases. Furthermore, secretory IgA is emerging as a major regulator of gut microbiota, which impacts intestinal homeostasis and global health as well. As such, IgA could be used to promote a healthy microbiota in a therapeutic setting. Key messages IgA combines multifaceted functions that can be desirable for immunotherapy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Inmunoglobulina A
/
SARS-CoV-2
/
Tratamiento Farmacológico de COVID-19
/
Inmunoterapia
/
Anticuerpos Monoclonales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacology
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia