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Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-ß-cyclodextrin: A biosensor evaluation and interaction study.
Li, Shuying; Zhang, Ying; Khan, Abdur Rauf; He, Shuwang; Wang, Yingxin; Xu, Jiangkang; Zhai, Guangxi.
Afiliación
  • Li S; Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, 250012, China.
  • Zhang Y; Department of Pharmaceutical Development, Shandong Dyne Marine Biopharmaceutical Limited Corporation, Rongcheng, 264300, China.
  • Khan AR; Department of Pharmaceutical Development, Shandong Dyne Marine Biopharmaceutical Limited Corporation, Rongcheng, 264300, China.
  • He S; Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, 250012, China.
  • Wang Y; Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, 250012, China.
  • Xu J; Department of Pharmaceutical Development, Shandong Dyne Marine Biopharmaceutical Limited Corporation, Rongcheng, 264300, China.
  • Zhai G; Department of Pharmaceutical Development, Shandong Dyne Marine Biopharmaceutical Limited Corporation, Rongcheng, 264300, China.
Asian J Pharm Sci ; 15(4): 492-505, 2020 Jul.
Article en En | MEDLINE | ID: mdl-32952672
ABSTRACT
The bitterness of a drug is a major challenge for patient acceptability and compliance, especially for children. Due to the toxicity of medication, a human taste panel test has certain limitations. Atomoxetine hydrochloride (HCl), which is used for the treatment of attention deficit/hyperactivity disorder (ADHD), has an extremely bitter taste. The aim of this work is to quantitatively predict the bitterness of atomoxetine HCl by a biosensor system. Based on the mechanism of detection of the electronic tongue (E-tongue), the bitterness of atomoxetine HCl was evaluated, and it was found that its bitterness was similar to that of quinine HCl. The bitterness threshold of atomoxetine HCl was 8.61 µg/ml based on the Change of membrane Potential caused by Adsorption (CPA) value of the BT0 sensor. In this study, the taste-masking efficiency of 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CyD) was assessed by Euclidean distances on a principle component analysis (PCA) map with the SA402B Taste Sensing System, and the host-guest interactions were investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), nuclear magnetic resonance (NMR) spectroscopy and scanning electron microscopy (SEM). Biosensor evaluation and characterization of the inclusion complex indicated that atomoxetine HCl could actively react with 2-hydroxypropyl-ß-cyclodextrin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Asian J Pharm Sci Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Asian J Pharm Sci Año: 2020 Tipo del documento: Article País de afiliación: China