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Soft Contact Lens with Embedded Microtubes for Sustained and Self-Adaptive Drug Delivery for Glaucoma Treatment.
Ding, Xiaoke; Ben-Shlomo, Gil; Que, Long.
Afiliación
  • Ding X; Electrical and Computer Engineering Department, Iowa State University, Ames, Iowa 50011, United States.
  • Ben-Shlomo G; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, United States.
  • Que L; Electrical and Computer Engineering Department, Iowa State University, Ames, Iowa 50011, United States.
ACS Appl Mater Interfaces ; 12(41): 45789-45795, 2020 Oct 14.
Article en En | MEDLINE | ID: mdl-32960561
Because of the physiological and anatomical constraints of the eye, ophthalmic drug delivery is challenging. When applied topically, less than 1% of administered ophthalmic drugs reach the aqueous humor. The delivery of a drug within an efficient therapeutic concentration, to the required site of action, for an extended period of time, is complicated. Herein, a novel type of contact lens device, with embedded microtubes as drug containers, is reported. This device can provide a simple, noninvasive, extended drug release up to 45 days with higher bioavailability and lower risk for adverse effects. Another unique feature of the device is the release of drug triggered by stretching of the contact lens, indicating the possibility for achieving a self-adaptive drug release device for treating glaucoma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Soluciones Oftálmicas / Timolol / Glaucoma / Sistemas de Liberación de Medicamentos / Lentes de Contacto Hidrofílicos / Fluoresceínas Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Soluciones Oftálmicas / Timolol / Glaucoma / Sistemas de Liberación de Medicamentos / Lentes de Contacto Hidrofílicos / Fluoresceínas Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos