Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study.

Baby, Krishnaprasad; Maity, Swastika; Mehta, Chetan H; Suresh, Akhil; Nayak, Usha Y; Nayak, Yogendra

Baby, Krishnaprasad; Maity, Swastika; Mehta, Chetan H; Suresh, Akhil; Nayak, Usha Y; Nayak, Yogendra.

Afiliación

Baby K; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Maity S; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Mehta CH; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Suresh A; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Nayak UY; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Nayak Y; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India. Electronic address: yogendra.nayak@manipal.edu.

Arch Med Res ; 52(1): 38-47, 2021 01.

Article en En | MEDLINE | ID: mdl-32962867

Asunto(s)

Antivirales/uso terapéutico; Tratamiento Farmacológico de COVID-19; Proteasas 3C de Coronavirus/antagonistas & inhibidores; Reposicionamiento de Medicamentos/métodos; Inhibidores de Proteasas/uso terapéutico; SARS-CoV-2/enzimología; Antivirales/química; Antivirales/farmacología; COVID-19/virología; Proteasas 3C de Coronavirus/química; Proteasas 3C de Coronavirus/metabolismo; Descubrimiento de Drogas/métodos; Humanos; Simulación del Acoplamiento Molecular/métodos; Simulación de Dinámica Molecular; Terapia Molecular Dirigida; Inhibidores de Proteasas/química; Inhibidores de Proteasas/farmacología; SARS-CoV-2/efectos de los fármacos

Palabras clave

COVID-19; Docking; In silico; M(pro); Repurposing; SARS-CoV-2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Reposicionamiento de Medicamentos / Proteasas 3C de Coronavirus / SARS-CoV-2 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arch Med Res Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: India

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