Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.

Zhou, Jie; Li, Shantao; Leung, Kevin K; O'Donovan, Brian; Zou, James Y; DeRisi, Joseph L; Wells, James A

Zhou, Jie; Li, Shantao; Leung, Kevin K; O'Donovan, Brian; Zou, James Y; DeRisi, Joseph L; Wells, James A.

Afiliación

Zhou J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Li S; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
O'Donovan B; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Zou JY; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
DeRisi JL; Chan Zuckerberg Biohub, San Francisco, CA 94158.
Wells JA; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.

Proc Natl Acad Sci U S A ; 117(41): 25464-25475, 2020 10 13.

Article en En | MEDLINE | ID: mdl-32973096

Asunto(s)

Caspasa 3/metabolismo; Proteoma; Caspasa 3/genética; Regulación Enzimológica de la Expresión Génica; Humanos; Biblioteca de Péptidos; Especificidad por Sustrato

Palabras clave

NGS; human proteome; protease specificity; substrate phage library

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteoma / Caspasa 3 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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