Your browser doesn't support javascript.
loading
One-Year Post Hoc Analysis of Renal Function for Live Kidney Donors That Were Enrolled in an Enhanced Recovery After Surgery Pathway With Ketorolac.
Campsen, Jeffrey; Zhang, Chong; Presson, Angela; Goodale, Mariah; Pan, Gilbert; Scutts, Sarah; Rofaiel, George; Kim, Robin.
Afiliación
  • Campsen J; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Zhang C; Department of Medicine, Division of Epidemiology, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Presson A; Department of Medicine, Division of Epidemiology, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Goodale M; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Pan G; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Scutts S; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Rofaiel G; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
  • Kim R; Department of Surgery, Division of Transplantation and Advanced Hepatobiliary Surgery, University of Utah School of Medicine/Huntsman Cancer Institute, Salt Lake City, USA.
Cureus ; 12(8): e10056, 2020 Aug 26.
Article en En | MEDLINE | ID: mdl-32999779
Background and Objective Opioid exposure is a concern after live donation for kidney transplants (LDKT). We previously theorized that an enhanced recovery after surgery (ERAS) pathway for LDKT will reduce perioperative narcotic use. The aim of this post hoc analysis of merged data from two ERAS trials was to review the one-year follow-up to determine if the exposure to ketorolac versus placebo had any significant impact on long-term kidney function after LDKT. Methods One-year post hoc analysis of merged data from two ERAS LDKT, prospective, double-blind, randomized clinical trials were combined involving a total of 72 patients undergoing nephrectomy for LDKT. Kidney functions of both the ERAS groups' versus placebo were compared prospectively and blinded at one year using estimated glomerular filtration rate (eGFR) and total protein (TP) in the urine in compliance with United Network for Organ Sharing (UNOS) live donor requirements. Results There was no significant difference in postoperative eGFR at one year between ERAS and placebo groups. TP urine at one-year post-operative was significantly lower in the ERAS cohort by 4.7 mg/dl (95% CI 0.48 ~ 8.82, p = 0.025). Conclusions The ERAS groups' exposure to ketorolac did not negatively affect kidney function at one year after LDKT.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Cureus Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Cureus Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos