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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.
Rynearson, Kevin D; Buckle, Ronald N; Herr, R Jason; Mayhew, Nicholas J; Chen, Xinchao; Paquette, William D; Sakwa, Samuel A; Yang, Jinhai; Barnes, Keith D; Nguyen, Phuong; Mobley, William C; Johnson, Graham; Lin, Juinn H; Tanzi, Rudolph E; Wagner, Steven L.
Afiliación
  • Rynearson KD; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, United States. Electronic address: krynearson@ucsd.edu.
  • Buckle RN; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Herr RJ; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Mayhew NJ; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Chen X; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Paquette WD; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Sakwa SA; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Yang J; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Barnes KD; Department of Medicinal Chemistry, AMRI, East Campus, 3 University Place, Rensselaer, NY 12144, United States.
  • Nguyen P; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, United States.
  • Mobley WC; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, United States.
  • Johnson G; NuPharmAdvise, 3 Lakeside Drive, Sanbornton, NH 03269, United States.
  • Lin JH; Biopharm Consulting Partners, 2 Willet Drive, Ambler, PA 19002, United States.
  • Tanzi RE; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, United States.
  • Wagner SL; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, United States; Veterans Administrative San Diego Healthcare System, La Jolla, CA 92161, United States. Electronic address: slwagner@health.ucsd.edu.
Bioorg Med Chem ; 28(22): 115734, 2020 11 15.
Article en En | MEDLINE | ID: mdl-33007551
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Diseño de Fármacos / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide Límite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridinas / Diseño de Fármacos / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide Límite: Animals / Female / Humans / Male Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido