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Sex Differences in Mortality Rates and Underlying Conditions for COVID-19 Deaths in England and Wales.
Mohamed, Mohamed O; Gale, Chris P; Kontopantelis, Evangelos; Doran, Tim; de Belder, Mark; Asaria, Miqdad; Luscher, Thomas; Wu, Jianhua; Rashid, Muhammad; Stephenson, Courtney; Denwood, Tom; Roebuck, Chris; Deanfield, John; Mamas, Mamas A.
Afiliación
  • Mohamed MO; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, Keele, United Kingdom; Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom.
  • Gale CP; Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom; Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
  • Kontopantelis E; Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom.
  • Doran T; Department of Health Sciences, University of York, York, United Kingdom.
  • de Belder M; National Institute for Cardiovascular Outcomes Research, Barts Health NHS Trust, United Kingdom.
  • Asaria M; London School of Economics, London, United Kingdom.
  • Luscher T; Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
  • Wu J; Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom.
  • Rashid M; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, Keele, United Kingdom; Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom.
  • Stephenson C; NHS Digital, Leeds, United Kingdom.
  • Denwood T; NHS Digital, Leeds, United Kingdom.
  • Roebuck C; NHS Digital, Leeds, United Kingdom.
  • Deanfield J; University College London, London, United Kingdom.
  • Mamas MA; Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, Keele, United Kingdom; Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom. Electronic address: mam
Mayo Clin Proc ; 95(10): 2110-2124, 2020 10.
Article en En | MEDLINE | ID: mdl-33012342
ABSTRACT

OBJECTIVE:

To address the issue of limited national data on the prevalence and distribution of underlying conditions among COVID-19 deaths between sexes and across age groups. PATIENTS AND

METHODS:

All adult (≥18 years) deaths recorded in England and Wales (March 1, 2020, to May 12, 2020) were analyzed retrospectively. We compared the prevalence of underlying health conditions between COVID and non-COVID-related deaths during the COVID-19 pandemic and the age-standardized mortality rate (ASMR) of COVID-19 compared with other primary causes of death, stratified by sex and age group.

RESULTS:

Of 144,279 adult deaths recorded during the study period, 36,438 (25.3%) were confirmed COVID deaths. Women represented 43.2% (n=15,731) of COVID deaths compared with 51.9% (n=55,980) in non-COVID deaths. Overall, COVID deaths were younger than non-COVID deaths (82 vs 83 years). ASMR of COVID-19 was higher than all other common primary causes of death, across age groups and sexes, except for cancers in women between the ages of 30 and 79 years. A linear relationship was observed between ASMR and age among COVID-19 deaths, with persistently higher rates in men than women across all age groups. The most prevalent reported conditions were hypertension, dementia, chronic lung disease, and diabetes, and these were higher among COVID deaths. Pre-existing ischemic heart disease was similar in COVID (11.4%) and non-COVID (12%) deaths.

CONCLUSION:

In a nationwide analysis, COVID-19 infection was associated with higher age-standardized mortality than other primary causes of death, except cancer in women of select age groups. COVID-19 mortality was persistently higher in men and increased with advanced age.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Mortalidad Hospitalaria / Infecciones por Coronavirus / Disparidades en Atención de Salud / Betacoronavirus Tipo de estudio: Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Mayo Clin Proc Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Mortalidad Hospitalaria / Infecciones por Coronavirus / Disparidades en Atención de Salud / Betacoronavirus Tipo de estudio: Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Mayo Clin Proc Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
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