Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.

Walser, Franziska; Mulder, Monique P C; Bragantini, Benoît; Burger, Sibylle; Gubser, Tatiana; Gatti, Marco; Botuyan, Maria Victoria; Villa, Alessandra; Altmeyer, Matthias; Neri, Dario; Ovaa, Huib; Mer, Georges; Penengo, Lorenza

Walser, Franziska; Mulder, Monique P C; Bragantini, Benoît; Burger, Sibylle; Gubser, Tatiana; Gatti, Marco; Botuyan, Maria Victoria; Villa, Alessandra; Altmeyer, Matthias; Neri, Dario; Ovaa, Huib; Mer, Georges; Penengo, Lorenza.

Afiliación

Walser F; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.
Mulder MPC; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands; Oncode Institute and Department of Cell and Chemical Biology, Chemical Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Bragantini B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Burger S; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.
Gubser T; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.
Gatti M; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Villa A; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland.
Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
Neri D; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), 8093 Zurich, Switzerland.
Ovaa H; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands; Oncode Institute and Department of Cell and Chemical Biology, Chemical Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.
Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
Penengo L; Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland. Electronic address: penengo@imcr.uzh.ch.

Mol Cell ; 80(3): 423-436.e9, 2020 11 05.

Article en En | MEDLINE | ID: mdl-33022275

Asunto(s)

Daño del ADN/fisiología; Proteína 1 de Unión al Supresor Tumoral P53/metabolismo; Ubiquitina/metabolismo; Animales; Línea Celular; Línea Celular Tumoral; Cromatina/metabolismo; ADN/metabolismo; Roturas del ADN de Doble Cadena; Daño del ADN/genética; Reparación del ADN por Unión de Extremidades/genética; Reparación del ADN/genética; Proteínas de Unión al ADN/metabolismo; Histonas/metabolismo; Recombinación Homóloga/fisiología; Humanos; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Proteínas Nucleares/metabolismo; Fosforilación; Transducción de Señal/genética; Treonina/metabolismo; Proteína 1 de Unión al Supresor Tumoral P53/fisiología; Ubiquitina/genética; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitinación

Palabras clave

53BP1; BRCA1/BARD1; DDR; DNA damage response; DNA repair; H2AK15pUbT12; RAD51; RNF168; RNF169; RNF8; USP51; chromatin ubiquitination; genome stability; histone mark H2AK15ub; pUbT12; phospho-ubiquitin Thr12; ubiquitin phosphorylation

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Ubiquitina / Proteína 1 de Unión al Supresor Tumoral P53 Límite: Animals / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Suiza

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google