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Antitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605B.
Pérez, Víctor Tena; Ticona, Luis Apaza; Cabanillas, Alfredo H; Corral, Santiago Maderuelo; Perles, Josefina; Valencia, Diego Fernando Rosero; Quintana, Antera Martel; Domenech, Montserrat Ortega; Sánchez, Ángel Rumbero.
Afiliación
  • Pérez VT; Department of Organic Chemistry, Faculty of Sciences, University Autónoma of Madrid, Cantoblanco, 28049, Madrid, Spain.
  • Ticona LA; Department of Organic Chemistry, Faculty of Sciences, University Autónoma of Madrid, Cantoblanco, 28049, Madrid, Spain; Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain. Electronic address: lui
  • Cabanillas AH; Department of Organic Chemistry, Faculty of Sciences, University Autónoma of Madrid, Cantoblanco, 28049, Madrid, Spain.
  • Corral SM; Valoralia I más D SLU, Tres Cantos, 28760, Madrid, Spain.
  • Perles J; Single Crystal X-ray Diffraction Laboratory, Interdepartmental Research Service (SIdI), University Autónoma of Madrid, Cantoblanco, 28049, Madrid, Spain.
  • Valencia DFR; Valoralia I más D SLU, Tres Cantos, 28760, Madrid, Spain.
  • Quintana AM; Spanish Algae Bank, University of Las Palmas of Gran Canaria, 35214, Telde, Las Palmas, Canary Islands, Spain.
  • Domenech MO; Valoralia I más D SLU, Tres Cantos, 28760, Madrid, Spain. Electronic address: montsetaod@gmail.com.
  • Sánchez ÁR; Department of Organic Chemistry, Faculty of Sciences, University Autónoma of Madrid, Cantoblanco, 28049, Madrid, Spain.
Phytochemistry ; 180: 112529, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33032099
ABSTRACT
Three carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction. All compounds showed apoptotic capacity against the SK-MEL-1, SK-MEL-28 and SK-MEL-31 tumour cells. Carbamidocylindrofridin A had the highest anti-tumour potential, with an IC50 of 1 ± 0.3 µM in the SK-MEL-1 cell line.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cianobacterias País/Región como asunto: Europa Idioma: En Revista: Phytochemistry Año: 2020 Tipo del documento: Article País de afiliación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cianobacterias País/Región como asunto: Europa Idioma: En Revista: Phytochemistry Año: 2020 Tipo del documento: Article País de afiliación: España