Adherence to buprenorphine: An analysis of prescription drug monitoring program data.
Drug Alcohol Depend
; 216: 108317, 2020 11 01.
Article
en En
| MEDLINE
| ID: mdl-33035714
ABSTRACT
BACKGROUND:
Although buprenorphine is an evidence-based treatment for opioid use disorder (OUD), many individuals discontinue treatment soon after starting. This study assesses predictors of buprenorphine adherence using Prescription Drug Monitoring Program (PDMP) data.METHODS:
PDMP data for Philadelphia, Pennsylvania were used to measure 180-day adherence to buprenorphine among new initiates. Adherence was classified using percent days covered (PDC), and new initiates with PDC ≥ 0.80 were classified as adherent. Multivariable logistic regression was conducted to determine factors associated with buprenorphine adherence.RESULTS:
Between January 2017 and December 2018, 10,669 Philadelphia residents initiated buprenorphine and 26.6 % remained adherent after 180 days. Demographic factors associated with greater odds of adherence included age category and female sex (aOR 1.37; 95 % CI 1.25-1.50). Those filling an opioid prescription, other than buprenorphine, during the follow-up period had lower odds of adherence than those who did not fill an opioid prescription (aOR 0.62; 95 % CI 0.50-0.77). Odds of adherence was greater for those on the film formulation (aOR 1.37; 95 % CI 1.25-1.50) than the tablet formulation. Those filling medium (aOR 1.76; 95 % CI 1.55-2.00) and high dose (aOR 5.11; 95 % CI 4.30-6.17) buprenorphine prescriptions had higher odds of adherence than those filling low dose prescriptions.CONCLUSIONS:
Individual demographics, receipt of an opioid prescription, buprenorphine formulation, and buprenorphine dose were all associated with adherence to buprenorphine. Ongoing strategies to address OUD need to prioritize increasing retention in long-term evidence-based buprenorphine treatment while also encouraging providers to regularly consult the PDMP to ensure patient compliance.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Buprenorfina
/
Cumplimiento de la Medicación
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Tratamiento de Sustitución de Opiáceos
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Programas de Monitoreo de Medicamentos Recetados
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Analgésicos Opioides
/
Trastornos Relacionados con Opioides
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Implementation_research
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Drug Alcohol Depend
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos