Novel mutations in <i>BRCA2</i> intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors.

Chen, Hua-Dong; Guo, Ne; Song, Shan-Shan; Chen, Chuan-Huizi; Miao, Ze-Hong; He, Jin-Xue

Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors.

Chen, Hua-Dong; Guo, Ne; Song, Shan-Shan; Chen, Chuan-Huizi; Miao, Ze-Hong; He, Jin-Xue.

Afiliación

Chen HD; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203, P. R. China.
Guo N; University of Chinese Academy of Sciences No. 19A Yuquan Road, Beijing 100049, P. R. China.
Song SS; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203, P. R. China.
Chen CH; University of Chinese Academy of Sciences No. 19A Yuquan Road, Beijing 100049, P. R. China.
Miao ZH; Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203, P. R. China.
He JX; University of Chinese Academy of Sciences No. 19A Yuquan Road, Beijing 100049, P. R. China.

Am J Cancer Res ; 10(9): 2813-2831, 2020.

Article en En | MEDLINE | ID: mdl-33042619

Palabras clave

BIRC3; BRCA2; COX-2; PARP inhibitors resistance; apoptotic resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Am J Cancer Res Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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