[Effect of benzydamine on release of prostaglandin E2 and prostacyclin from rabbit gastric mucosa cells]. / Einfluss von Benzydamin auf die Freisetzung von Prostaglandin E2 und Prostazyklin aus Magenschleimhautzellen des Kaninchens.

ABSTRACT

The effect of the antiinflammatory drug benzydamine (Tantum) on prostaglandin E2 (PGE2) release from rabbit gastric mucosal cells was investigated. Up to 1 mmol/l benzydamine had no significant effect on PGE2 and prostacyclin (PGI2) formation and release. The lack of interference with gastric mucosal prostaglandin synthesis might explain the non-ulcerogenicity of this compound compared to other non-steroidal antiinflammatory drugs (e.g. indomethacin).