Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer.
Nanoscale
; 12(40): 20598-20603, 2020 Oct 22.
Article
en En
| MEDLINE
| ID: mdl-33047748
ABSTRACT
Novel conjugated carbon dots (CDs) were synthesized as two-photon active photosensitisers to unleash lethal reactive oxygen species (ROS) for nucleus-targeting photodynamic therapy (PDT). To enhance the therapeutic efficiency and preclude non-specific CD uptake, we employed a combination of folic acid and curcumin for two-photon NIR-triggered ROS generation and enhanced internalization in the nucleus. Consequently, enhanced destruction of cancer cells occurred by directly attacking the DNA. The intrinsic ROS generation and nucleus-targeting ability of CDs introduced multifunctional two-photon active nanoprobes within a single platform for enhanced PDT in oral cancer theranostics.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Neoplasias de la Boca
Límite:
Humans
Idioma:
En
Revista:
Nanoscale
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia