Your browser doesn't support javascript.
loading
Insights into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions.
Berekaa, Mahmoud M.
Afiliación
  • Berekaa MM; Department of Environmental Health, College of Public Health, Imam Abdulrahman Bin Faisal University, P.O.Box 1982, Dammam 31441, Saudi Arabia, mberekaa@iau.edu.sa.
Front Biosci (Elite Ed) ; 13: 117-139, 2021 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-33048778
ABSTRACT
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the human coronavirus (HCoV) family that targets the lower part of the respiratory tract and causes severe acute respiratory syndrome (SARS). In a short span of time, this infection has led to a global pandemic and has become a significant threat to the existence of present human society. Currently, there are no treatments for this infection and the measures established across various countries such as social distancing, usage of mask to prevent entry of the virus into the respiratory tract, quarantine, and containment together have reduced the prevalence of this disease and mortality in highly susceptible individuals. Here, we examine the structure, replication cycle, phylogeny and genomic organization of this virus and discuss the role of spike (S) protein of the virus, an important structure that interacts with the host ACE2 receptor facilitating viral entry. Further, we explore the epidemiology, symptoms of the disease, describe the reverse transcriptase-polymerase chain reaction (RT-PCR) that establishes the diagnosis of the disease and also review its unique diagnostic features in the chest CT-Scan. Finally, we review the current approaches to develop therapies and vaccines as a measure for disease prevention and control.
Asunto(s)
Buscar en Google
Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar Tema en salud: Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Pandemias / Betacoronavirus Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Front Biosci (Elite Ed) Asunto de la revista: Biologia Año: 2021 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Buscar en Google
Colección: Bases de datos internacionales Contexto en salud: ODS3 - Salud y Bienestar Tema en salud: Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Pandemias / Betacoronavirus Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Front Biosci (Elite Ed) Asunto de la revista: Biologia Año: 2021 Tipo del documento: Artículo