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Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Harper, Sara A; Bassler, John R; Peramsetty, Sujitha; Yang, Youfeng; Roberts, Lisa M; Drummer, Devin; Mankowski, Robert T; Leeuwenburgh, Christiaan; Ricart, Karina; Patel, Rakesh P; Bamman, Marcas M; Anton, Stephen D; Jaeger, Byron C; Buford, Thomas W.
Afiliación
  • Harper SA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Kinesiology and Health Science Department, Utah State University, Logan, UT, USA; Sorenson Legacy Foundation Center for Clinical E
  • Bassler JR; Department of Biostatistics, University of Alabama at Birmingham, AL, USA. Electronic address: jbassle1@uab.edu.
  • Peramsetty S; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: gperam@uab.edu.
  • Yang Y; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: youfengyang@uabmc.edu.
  • Roberts LM; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lmroberts@uab
  • Drummer D; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: drummerd@uab.edu.
  • Mankowski RT; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: r.mankowski@uflu.edu.
  • Leeuwenburgh C; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: cleeuwen@flu.edu.
  • Ricart K; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: karinaricart@uabmc.edu.
  • Patel RP; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: rakeshpatel@uabmc.edu.
  • Bamman MM; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: mbamman@uab.edu.
  • Anton SD; Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: santon@ufl.edu.
  • Jaeger BC; Department of Biostatistics, University of Alabama at Birmingham, AL, USA. Electronic address: bcjaeger@uab.edu.
  • Buford TW; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA; UAB Nathan Shock Center on the Ba
Exp Gerontol ; 143: 111111, 2021 01.
Article en En | MEDLINE | ID: mdl-33068691
ABSTRACT

PURPOSE:

To evaluate the safety and feasibility of combining exercise (EX) and resveratrol to treat older adults with physical function limitations.

METHODS:

Three-arm, two-site pilot randomized, controlled trial (RCT) for community-dwelling adults (N = 60), 71.8 ± 6.3 years of age with functional limitations. Participants were randomized to receive either 12 weeks of (1) EX + placebo [EX0], (2) EX + 500 mg/day resveratrol [EX500], or (3) EX + 1000 mg/day resveratrol [EX1000]. EX consisted of two sessions a week for 12 weeks of center-based walking and whole-body resistance training. Safety was assessed through adverse events and feasibility through exercise session and supplement (placebo, or resveratrol) protocol adherence. Outcome measures included a battery of indices of physical function as well as skeletal muscle mitchondrial function. Data were adjusted for age and gender using the Intent-To-Treat approach.

RESULTS:

Adverse event frequency and type were similar between groups (n = 8 EX0, n = 12 EX500, and n = 7 EX1000). Overall, 85% of participants met the supplement adherence via pill counts while 82% met the exercise session adherence. Adjusted within group mean differences (95% confidence interval) from week 0 to 12 for gait speed ranged from -0.04 (EX0 -0.1, 0.03) m/s to 0.04 (EX1000 -0.02, 0.11) and the six-minute walk test mean differences were 9.45 (EX0 -9.02, 27.7), 22.9 (EX500 4.18, 41.6), and 33.1 (EX1000 13.8, 52.4) meters. Unadjusted mean differences for citrate synthase were -0.80 (EX0 -15.45, 13.84), -1.38 (EX500 -12.16, 9.39), and 7.75 (EX1000 -4.68, 20.18) mU/mg. COX activity mean within group changes ranged from -0.05 (EX0) to 0.06 (EX500) k/s/mg. Additional outcomes are detailed in the text.

CONCLUSION:

The pilot RCT indicated that combined EX + resveratrol was safe and feasible for older adults with functional limitations and may improve skeletal muscle mitochondrial function and mobility-related indices of physical function. A larger trial appears warranted and is needed to formally test these hypotheses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Caminata Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Exp Gerontol Año: 2021 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Caminata Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Exp Gerontol Año: 2021 Tipo del documento: Article