Amino acid recognition by a fluorescent chemosensor based on cucurbit[8]uril and acridine hydrochloride.
Anal Chim Acta
; 1135: 142-149, 2020 Oct 23.
Article
en En
| MEDLINE
| ID: mdl-33070851
ABSTRACT
A new fluorescent chemosensor comprised of cucurbit[8]uril (Q[8]) and acridine hydrochloride (AC) has been designed and utilized for the recognition of amino acids. The AC was encapsulated by the Q[8] cavity and formed a 12 host-guest inclusion complex both in solution (aqueous) and in the solid-state. Whilst free AC is known to be strongly fluorescent, this strong fluorescence was quenched in the inclusion complex Q [8]-AC. This non-fluorescent complex Q[8]-AC was capable of serving as a fluorescence "off-on" probe, and was able to recognize either L-Phe or L-Trp via the competitive interaction between L-Phe or L-Trp. Moreover, the pH responsive nature of the probe allowed for the detection of basic amino acids, namely L-Arg, L-His, or L-Lys). As a result, a fluorescence method for the detection of five amino acids using a single system has been developed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acridinas
/
Aminoácidos
Idioma:
En
Revista:
Anal Chim Acta
Año:
2020
Tipo del documento:
Article
País de afiliación:
China