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Bioengineering tools for probing intracellular events in T lymphocytes.
Zhang, Xinyuan; Mariano, Chelsea F; Ando, Yuta; Shen, Keyue.
Afiliación
  • Zhang X; Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
  • Mariano CF; Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
  • Ando Y; Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
  • Shen K; Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA.
WIREs Mech Dis ; 13(4): e1510, 2021 07.
Article en En | MEDLINE | ID: mdl-33073545
ABSTRACT
T lymphocytes are the central coordinator and executor of many immune functions. The activation and function of T lymphocytes are mediated through the engagement of cell surface receptors and regulated by a myriad of intracellular signaling network. Bioengineering tools, including imaging modalities and fluorescent probes, have been developed and employed to elucidate the cellular events throughout the functional lifespan of T cells. A better understanding of these events can broaden our knowledge in the immune systems biology, as well as accelerate the development of effective diagnostics and immunotherapies. Here we review the commonly used and recently developed techniques and probes for monitoring T lymphocyte intracellular events, following the order of intracellular events in T cells from activation, signaling, metabolism to apoptosis. The techniques introduced here can be broadly applied to other immune cells and cell systems. This article is categorized under Immune System Diseases > Molecular and Cellular Physiology Immune System Diseases > Biomedical Engineering Infectious Diseases > Biomedical Engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Linfocitos T Idioma: En Revista: WIREs Mech Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Antígenos de Linfocitos T / Linfocitos T Idioma: En Revista: WIREs Mech Dis Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos