Visually cued fear conditioning test for memory impairment related to cortical function.
Neuropsychopharmacol Rep
; 40(4): 371-375, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33089673
ABSTRACT
AIM:
Fear conditioning tests are intended to elucidate a subject's ability to associate a conditioned stimulus with an aversive, unconditioned stimulus, such as footshock. Among these tests, a paradigm related to precise cortical functions would be increasingly important in drug screening for disorders such as schizophrenia and dementia. Therefore, we established a new fear conditioning paradigm using a visual cue in mice. In addition, the validity of the test was evaluated using a genetically engineered mouse, heterozygous deficient in Mdga1 (Mdga1+/-), which is related to schizophrenia.RESULTS:
Mice were given footshocks associated with a visual cue of moving gratings at training in 25-minute sessions. The mice showed the conditioned response of freezing behavior to the visual stimulus at testing 24 hours after the footshocks. In the test for validation, the Mdga1+/- deficient mice showed significantly less freezing than wild-type mice.CONCLUSION:
The visually cued fear conditioning paradigm with moving gratings has been established, which is experimentally useful to evaluate animal cortical functions. The validity of the test was confirmed for Mdga1-deficient mice with possible deficiency in cortical functions.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Visual
/
Condicionamiento Operante
/
Señales (Psicología)
/
Miedo
/
Trastornos de la Memoria
/
Percepción de Movimiento
Límite:
Animals
Idioma:
En
Revista:
Neuropsychopharmacol Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón