LRP1 polymorphisms associated with warfarin stable dose in Chinese patients: a stepwise conditional analysis.
Pharmacogenomics
; 21(16): 1169-1178, 2020 11.
Article
en En
| MEDLINE
| ID: mdl-33094665
ABSTRACT
Aim:
The aim of this study was to investigate whether variability in warfarin stable dose (WSD) could be influenced by vitamin K-related polymorphisms in patients with heart valve replacement. Patients &methods:
Twenty-nine vitamin K-related SNPs in 208 patients who initially took warfarin and achieved WSD were genotyped.Results:
After conducting conditional analysis for both VKORC1 -1639G>A and CYP2C9*3, LRP1 rs1800139 and LRP1 rs1800154 were significantly associated with WSD (p = 0.007 and p = 0.015, respectively). Multivariate analysis showed that LRP1 rs1800139 accounted for 5.9% WSD variability.Conclusion:
Our results suggest that a novel vitamin K-related gene, LRP1, exerts a relevant influence on WSD, independent of VKORC1 -1639G>A and CYP2C9*3.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Warfarina
/
Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad
/
Anticoagulantes
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2020
Tipo del documento:
Article