Host Defense Peptides as Templates for Antifungal Drug Development.
J Fungi (Basel)
; 6(4)2020 Oct 23.
Article
en En
| MEDLINE
| ID: mdl-33113935
ABSTRACT
Current treatment for invasive fungal diseases is limited to three classes of antifungal drugs azoles, polyenes, and echinocandins. The most recently introduced antifungal class, the echinocandins, was first approved nearly 30 years ago. The limited antifungal drug portfolio is rapidly losing its clinical utility due to the inexorable rise in the incidence of invasive fungal infections and the emergence of multidrug resistant (MDR) fungal pathogens. New antifungal therapeutic agents and novel approaches are desperately needed. Here, we detail attempts to exploit the antifungal and immunoregulatory properties of host defense peptides (HDPs) in the design and evaluation of new antifungal therapeutics and discuss historical limitations and recent advances in this quest.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Fungi (Basel)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos