Defect-Rich Adhesive Molybdenum Disulfide/rGO Vertical Heterostructures with Enhanced Nanozyme Activity for Smart Bacterial Killing Application.
Adv Mater
; 32(48): e2005423, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-33118265
ABSTRACT
Nanomaterials with intrinsic enzyme-like activities, namely "nanozymes," are showing increasing potential as a new type of broad-spectrum antibiotics. However, their feasibility is still far from satisfactory, due to their low catalytic activity, poor bacterial capturing capacity, and complicated material design. Herein, a facile synthesis of a defect-rich adhesive molybdenum disulfide (MoS2 )/rGO vertical heterostructure (VHS) through a one-step microwave-assisted hydrothermal method is reported. This simple, convenient but effective method for rapid material synthesis enables extremely uniform and well-dispersed MoS2 /rGO VHS with abundant S and Mo vacancies and rough surface, for a performance approaching the requirements of practical application. It is demonstrated experimentally and theoretically that the as-prepared MoS2 /rGO VHS possesses defect and irradiation dual-enhanced triple enzyme-like activities (oxidase, peroxidase, and catalase) for promoting free-radical generation, owing to much more active edge sites exposure. Meanwhile, the VHS-achieved rough surface exhibits excellent capacity for bacterial capture, with elevated reactive oxygen species (ROS) destruction through local topological interactions. As a result, optimized efficacy against drug-resistant Gram-negative and Gram-positive bacteria can be explored by such defect-rich adhesive nanozymes, demonstrating a simple but powerful way to engineered nanozymes for alternative antibiotics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Nanoestructuras
/
Disulfuros
/
Viabilidad Microbiana
/
Grafito
/
Antibacterianos
/
Molibdeno
Idioma:
En
Revista:
Adv Mater
Asunto de la revista:
BIOFISICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article