Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs).
Nat Prod Rep
; 38(4): 757-781, 2021 04 28.
Article
en En
| MEDLINE
| ID: mdl-33118578
ABSTRACT
Covering 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a subfamily of the nuclear receptor superfamily and possess prominent roles in circadian rhythm, metabolism, inflammation, and cancer. They have been subject of research for over two decades and represent attractive but challenging drug targets. Natural products were among the first identified ligands of RORs and continue to be of interest to this day. This review focuses on ligands and indirect modulators of RORs from natural sources and explores their roles in a therapeutic context.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Receptores de Ácido Retinoico
/
Receptores Nucleares Huérfanos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Prod Rep
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Austria