Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia.
Hypertens Pregnancy
; 39(4): 451-460, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-33119997
ABSTRACT
Introduction:
Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction.Methods:
Sprague Dawley rats had RUPP surgery with/without AT1-AA inhibitor ('n7AAc'144 µg/day) osmotic minipumps. Mean arterial pressure (MAP), CBF autoregulation, blood brain barrier (BBB) permeability, cerebral edema, oxidative stress, and eNOS were assessed.Results:
'n7AAc' improved MAP, restored CBF autoregulation, prevented cerebral edema, elevated oxidative stress, and increased phosphorylated eNOS protein in RUPP rats.Conclusion:
Inhibiting the AT1-AA in placental ischemic rats prevents hypertension, cerebrovascular dysfunction, and improves cerebral metabolic function.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Presión Sanguínea
/
Circulación Cerebrovascular
/
Receptor de Angiotensina Tipo 1
/
Homeostasis
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Hypertens Pregnancy
Asunto de la revista:
ANGIOLOGIA
/
OBSTETRICIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos