3'-UTR, 3'-untranslated region; AAV, adeno-associated virus; CPT, carnitine palmitoyl transferase; DEG, differentially expressed gene; DEX, dexamethasone; DM, diabetes mellitus; DNL, de novo lipogenesis; Diabetes mellitus; FA, fatty acid; FAO, fatty acid oxidation; FASN, fatty acid synthase; GCR, glucocorticoid receptor; Glucocorticoid receptor; HFD, high-fat diet; HFrD, high-fructose drink; HOMA-IR, homeostatic model assessment of insulin resistance; Hepatic steatosis; High carbohydrate consumption; MicroRNA; NAFLD, non-alcoholic fatty liver disease; NR3C1, nuclear receptor subfamily 3, group C, member 1; NT, non-targeting; OA, oleic acid; OGTT, oral glucose tolerance test; SCD1, stearoyl-CoA desaturase-1; T2DM, type 2 diabetes mellitus; TAG, triacylglyceride/triglyceride; Transcription repressor; VAT, visceral adipose tissue; miRNA, microRNA; shRNA, short hairpin RNA