T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.

Zhang, Qin; Du, Xiaotian; He, Qiangqiang; Shi, Wei; Mei, Liu; Qv, Meiyu; Tan, Dan; Wu, Junsong; Zeng, Ling-Hui; Wu, Ximei

Zhang, Qin; Du, Xiaotian; He, Qiangqiang; Shi, Wei; Mei, Liu; Qv, Meiyu; Tan, Dan; Wu, Junsong; Zeng, Ling-Hui; Wu, Ximei.

Afiliación

Zhang Q; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Du X; Department of Orthopedic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
He Q; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Shi W; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Mei L; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Qv M; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Tan D; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Wu J; Department of Orthopedic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zeng LH; Department of Pharmacology, Zhejiang University City College, Hangzhou 310015, China. Electronic address: zenglh@zucc.edu.cn.
Wu X; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: xiwu@zju.edu.cn.

Life Sci ; 264: 118655, 2021 Jan 01.

Article en En | MEDLINE | ID: mdl-33141042

Asunto(s)

Mutación/genética; Proteínas Serina-Treonina Quinasas/genética; Proteínas Supresoras de Tumor/genética; Secuencia de Aminoácidos; Animales; Línea Celular Tumoral; Células HEK293; Vía de Señalización Hippo; Humanos; Masculino; Ratones Desnudos; Modelos Moleculares; Dominios Proteicos; Proteínas Serina-Treonina Quinasas/química; Proteínas Serina-Treonina Quinasas/metabolismo; Transducción de Señal; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Colorectal cancer; Hippo signaling; LATS1; Mutation

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / Proteínas Supresoras de Tumor / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Life Sci Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google