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A Systematic Review of the Value Assessment Frameworks Used within Health Technology Assessment of Omics Technologies and Their Actual Adoption from HTA Agencies.
Hoxhaj, Ilda; Govaerts, Laurenz; Simoens, Steven; Van Dyck, Walter; Huys, Isabelle; Gutiérrez-Ibarluzea, Iñaki; Boccia, Stefania.
Afiliación
  • Hoxhaj I; Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
  • Govaerts L; Healthcare Management Centre, Vlerick Business School, 9000 Ghent, Belgium.
  • Simoens S; Department of Pharmaceutical and Pharmacological Sciences, Catholic University of Leuven-KU Leuven, 3000 Leuven, Belgium.
  • Van Dyck W; Department of Pharmaceutical and Pharmacological Sciences, Catholic University of Leuven-KU Leuven, 3000 Leuven, Belgium.
  • Huys I; Healthcare Management Centre, Vlerick Business School, 9000 Ghent, Belgium.
  • Gutiérrez-Ibarluzea I; Department of Pharmaceutical and Pharmacological Sciences, Catholic University of Leuven-KU Leuven, 3000 Leuven, Belgium.
  • Boccia S; Department of Pharmaceutical and Pharmacological Sciences, Catholic University of Leuven-KU Leuven, 3000 Leuven, Belgium.
Artículo en Inglés | MEDLINE | ID: mdl-33143182
ABSTRACT

BACKGROUND:

Omics technologies, enabling the measurements of genes (genomics), mRNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics), are valuable tools for personalized decision-making. We aimed to identify the existing value assessment frameworks used by health technology assessment (HTA) doers for the evaluation of omics technologies through a systematic review.

METHODS:

PubMed, Scopus, Embase and Web of Science databases were searched to retrieve potential eligible articles published until 31 May 2020 in English. Additionally, through a desk research in HTA agencies' repositories, we retrieved the published reports on the practical use of these frameworks.

RESULTS:

Twenty-three articles were included in the systematic review. Twenty-two frameworks, which addressed genetic and/or genomic technologies, were described. Most of them derived from the ACCE framework and evaluated the domains of analytical validity, clinical validity and clinical utility. We retrieved forty-five reports, which mainly addressed the commercial transcriptomic prognostics and next generation sequencing, and evaluated clinical effectiveness, economic aspects, and description and technical characteristics.

CONCLUSIONS:

A value assessment framework for the HTA evaluation of omics technologies is not standardized and accepted, yet. Our work reports that the most evaluated domains are analytical validity, clinical validity and clinical utility and economic aspects.
Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Evaluación de tecnologías sanitárias / Patient_preference / Estudio pronóstico / Revisión sistemática Aspecto: Preferencia del paciente Idioma: Inglés Año: 2020 Tipo del documento: Artículo País de afiliación: Italia

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo de estudio: Evaluación de tecnologías sanitárias / Patient_preference / Estudio pronóstico / Revisión sistemática Aspecto: Preferencia del paciente Idioma: Inglés Año: 2020 Tipo del documento: Artículo País de afiliación: Italia