L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.

Huang, Longjian; Lan, Jiaqi; Tang, Jingshu; Kang, Yuying; Feng, Xinhong; Wu, Lei; Peng, Ying

Huang, Longjian; Lan, Jiaqi; Tang, Jingshu; Kang, Yuying; Feng, Xinhong; Wu, Lei; Peng, Ying.

Afiliación

Huang L; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China.
Lan J; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China.
Tang J; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China.
Kang Y; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China.
Feng X; Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Wu L; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China.
Peng Y; Pharmacology Department, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1, Xiannongtan Street, Xicheng District, Beijing, 100050, China. ypeng@imm.ac.cn.

Mol Neurobiol ; 58(3): 1260-1274, 2021 Mar.

Article en En | MEDLINE | ID: mdl-33146400

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Benzofuranos/uso terapéutico; Espinas Dendríticas/patología; Hipocampo/patología; Neuritas/patología; Plasticidad Neuronal/efectos de los fármacos; Sinapsis/patología; Enfermedad de Alzheimer/complicaciones; Enfermedad de Alzheimer/patología; Enfermedad de Alzheimer/fisiopatología; Animales; Autofagosomas/efectos de los fármacos; Autofagosomas/metabolismo; Autofagia/efectos de los fármacos; Axones/efectos de los fármacos; Axones/metabolismo; Axones/patología; Benzofuranos/farmacología; Biomarcadores/metabolismo; Células Cultivadas; Disfunción Cognitiva/tratamiento farmacológico; Espinas Dendríticas/efectos de los fármacos; Modelos Animales de Enfermedad; Hipocampo/ultraestructura; Potenciación a Largo Plazo/efectos de los fármacos; Lisosomas/efectos de los fármacos; Lisosomas/metabolismo; Masculino; Ratones Transgénicos; Prueba del Laberinto Acuático de Morris; Neuritas/efectos de los fármacos; Neuritas/metabolismo; Sinapsis/efectos de los fármacos

Palabras clave

Alzheimer's disease; Cognition; Dendritic spine; L-3-n-Butylphthalide (L-NBP); Synapse

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Benzofuranos / Neuritas / Espinas Dendríticas / Enfermedad de Alzheimer / Hipocampo / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Mol Neurobiol Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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