Risk of pre-term births and major birth defects resulting from paternal intake of COVID-19 medications prior to conception.
BMC Res Notes
; 13(1): 509, 2020 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-33160408
ABSTRACT
OBJECTIVE:
With the ongoing COVID-19 pandemic, large numbers of people will receive one of the several medications proposed to treat COVID-19, including patients of reproductive age. Given that some medications have shown adverse effects on sperm quality, there might be a transgenerational concern. We aim at examining the association between drugs proposed to treat COVID-19 when taken by the father around conception and any pre-term birth or major birth defects in offspring in a nation-wide cohort study using Danish registry data. Offspring whose father filled at least one prescription of the following medications in the 3 months preceding conception were considered exposed chloroquine, hydroxychloroquine, losartan, azithromycin, naproxen, dexamethasone and prednisone.RESULTS:
For azithromycin and naproxen, large numbers of offspring were exposed (> 1800 offspring), and we found no association with adverse birth outcomes. For chloroquine, losartan and dexamethasone, exposure was intermediate (~ 900 offspring), and there was no statistically significant association with birth defects. For hydroxychloroquine and prednisone, exposure was limited (< 300 offspring). Our evidence suggests that azithromycin and naproxen are safe with respect to pre-term birth and birth defects. For the other drugs investigated larger exposures are needed for conclusive statements.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Neumonía Viral
/
Anomalías Inducidas por Medicamentos
/
Infecciones por Coronavirus
/
Exposición Paterna
/
Nacimiento Prematuro
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMC Res Notes
Año:
2020
Tipo del documento:
Article
País de afiliación:
Dinamarca