Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth <i>in vitro</i> and <i>in vivo</i> partially through acetylation of p53.

Buyandelger, Batsaikhan; Bar, Eli E; Hung, Kuo-Sheng; Chen, Ruei-Ming; Chiang, Yung-Hsiao; Liou, Jing-Ping; Huang, Huei-Mei; Wang, Jia-Yi

Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53.

Buyandelger, Batsaikhan; Bar, Eli E; Hung, Kuo-Sheng; Chen, Ruei-Ming; Chiang, Yung-Hsiao; Liou, Jing-Ping; Huang, Huei-Mei; Wang, Jia-Yi.

Afiliación

Buyandelger B; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 110 Taipei, Taiwan.
Bar EE; Department of Neurology, Mongolian National University of Medical Sciences, 14210 Ulaanbaatar, Mongolia.
Hung KS; Department of Pathology and Neurosurgery, University of Maryland School of Medicine, 21201 Baltimore, MD, USA.
Chen RM; Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, 116 Taipei, Taiwan.
Chiang YH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 110 Taipei, Taiwan.
Liou JP; Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, 110 Taipei, Taiwan.
Huang HM; Neuroscience Research Center, Taipei Medical University, 110 Taipei, Taiwan.
Wang JY; School of Pharmacy, College of Pharmacy, Taipei Medical University, 110 Taipei, Taiwan.

Int J Biol Sci ; 16(16): 3184-3199, 2020.

Article en En | MEDLINE | ID: mdl-33162824

Asunto(s)

Antineoplásicos/farmacología; Glioma/tratamiento farmacológico; Inhibidores de Histona Desacetilasas/farmacología; Proteína p53 Supresora de Tumor/metabolismo; Acetilación; Animales; Astrocitos; Muerte Celular; Línea Celular Tumoral; Puntos de Control de la Fase G1 del Ciclo Celular; Humanos; Masculino; Ratones; Ratones Desnudos; Fosforilación; Ratas; Ratas Sprague-Dawley; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

HDAC6 inhibition; allograft; cell cycle arrest; cell death; glioma; xenograft

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Inhibidores de Histona Desacetilasas / Glioma / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: Int J Biol Sci Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Australia

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