Plasmodium berghei K13 Mutations Mediate <i>In Vivo</i> Artemisinin Resistance That Is Reversed by Proteasome Inhibition.

Simwela, Nelson V; Stokes, Barbara H; Aghabi, Dana; Bogyo, Matt; Fidock, David A; Waters, Andrew P

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition.

Simwela, Nelson V; Stokes, Barbara H; Aghabi, Dana; Bogyo, Matt; Fidock, David A; Waters, Andrew P.

Afiliación

Simwela NV; Institute of Infection, Immunity & Inflammation, Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom.
Stokes BH; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Aghabi D; Institute of Infection, Immunity & Inflammation, Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom.
Bogyo M; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Fidock DA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Waters AP; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA df2260@cumc.columbia.edu Andy.Waters@glasgow.ac.uk.

mBio ; 11(6)2020 11 10.

Article en En | MEDLINE | ID: mdl-33173001

Asunto(s)

Antimaláricos/farmacología; Artemisininas/farmacología; Resistencia a Medicamentos; Malaria/parasitología; Plasmodium berghei/efectos de los fármacos; Plasmodium berghei/genética; Inhibidores de Proteasoma/farmacología; Proteínas Protozoarias/genética; Animales; Femenino; Humanos; Malaria/tratamiento farmacológico; Ratones; Mutación/efectos de los fármacos; Plasmodium berghei/crecimiento & desarrollo; Plasmodium falciparum/genética; Plasmodium falciparum/metabolismo; Complejo de la Endopetidasa Proteasomal/genética; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteínas Protozoarias/metabolismo

Palabras clave

K13; Plasmodium berghei; Plasmodium falciparum; artemisinin resistance; gene editing; malaria; parasite clearance times; proteasome; ring-stage survival assays; synergy

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium berghei / Resistencia a Medicamentos / Proteínas Protozoarias / Artemisininas / Inhibidores de Proteasoma / Malaria / Antimaláricos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: MBio Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google