Combined stimuli of cold, hypoxia, and dehydration status on body temperature in rats: a pilot study with practical implications for humans.
BMC Res Notes
; 13(1): 530, 2020 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-33176867
ABSTRACT
OBJECTIVE:
As human thermoregulatory responses to maintain core body temperature (Tcore) under multiple stressors such as cold, hypoxia, and dehydration (e.g., exposure to high-altitude) are varied, the combined effects of cold, hypoxia, and dehydration status on Tcore in rats were investigated. The following environmental conditions were constructed (1) thermoneutral (24 °C) or cold (10 °C), (2) normoxia (21% O2) or hypoxia (12% O2), and (3) euhydration or dehydration (48 h water deprivation), resulted in eight environmental conditions [2 ambient temperatures (Ta) × 2 oxygen levels × 2 hydration statuses)]. Each condition lasted for 24 h.RESULTS:
Normoxic conditions irrespective of hypoxia or dehydration did not strongly decrease the area under the curve (AUC) in Tcore during the 24 period, whereas, hypoxic conditions caused greater decreases in the AUC in Tcore, which was accentuated with cold and dehydration (Ta × O2 × hydration, P = 0.040 by three-way ANOVA). In contrast, multiple stressors (Ta × O2 × hydration or Ta × O2 or O2 × hydration or Ta × hydration) did not affect locomotor activity counts (all P > 0.05), but a significant simple main effect for O2 and Ta was observed (P < 0.001). Heat loss index was not affected by all environmental conditions (all P > 0.05). In conclusion, decreases in Tcore were most affected by multiple environmental stressors such as cold, hypoxia, and dehydration.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Temperatura Corporal
/
Deshidratación
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
BMC Res Notes
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón